Pakistan Pharma

Montiget

 

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Montiget of Getz Pharma is a selective and orally active leukotrine receptor antagonist. Montiget inhibits the systeinyl leukotrine sysLT1 receptor, stimulation of which by circulating leukotrine in thought to play a role in the pathogenesis of Asthma. Montiget suppresses both early and late bronchoconstrictor resposes to inhale antigens or irritants, but is not suitable for the management of acute attacks of asthma. Montiget is chemically montelukast sodium.

Mechanism of Action

Montiget selectively antagonizes leukotrine D4 (LTD4) at the systeinyl leukotrine receptor, sysLT1, in the human airway. Montiget inhibits the action of LTD4 at the sysLT1 receptor, preventing airway edema smooth muscle contraction and enhance secretion of thick, viscous mucus.

Indications

Montiget is indicated in adult and paediatric patients six months of age and older for the prophylaxis in chronic treatment of asthma including;

  • The prevention of day and night time symptoms
  • The treatment of aspirin-sensitive asthmatic patients
  • The prevention of exercise-induced bronchoconstriction
  • Montiget is also indicated for the relief of the symptoms of allergic rhinitis

Contraindications

Montiget is contraindicated in a patient who has shown hypersensitivity to the drug or any of its components. Montiget is not indicated for use in acute asthma attacks including status asthmaticus.

Dosage

The Montiget should be taken once daily for the management of Asthma.

Available Strengths

  • Montiget 4mg Tablets
  • Montiget 5mg Tablets
  • Montiget 10mg Tablets
  • Montiget 4mg Granule

 

 Pakistan Pharma